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Sarcomatoid Mesothelioma

Mesothelioma is a rare form of cancer.  That attacks the lubricative layer lining certain organs as that in the chest and abdomen and the internal organs… Lungs (pleural mesothelioma), Abdomen (peritoneal mesothelioma) and Heart (pericardial mesothelioma).The only known cause for this deadly disease is exposure to asbestos. If you or a loved one has developed malignant mesothelioma, you may think of compensation from the company that caused you to be exposed to asbestos.

Sarcomatoid Mesothelioma

Pathologists categorize mesothelioma cancer cases according to Cellular Structure. That was determined by an actual visual examination of the cells under a microscope, and they are as follows:
Cellular Structure:
• Epithelial (organized and structured).
• Sarcomatoid (random and irregular).
• Biphasic (a mix of epithelial and sarcomatoid).
• Desoplastic (a variation of the sarcomatoid variety).
About Sarcomatoid Mesothelioma:
Sarcomatoid mesothelioma accounts are the least common of the mesothelioma cell types. It is for approximately 10 to 15 percent of all three major histological types of mesotheliomas and the most aggressive.
Sarcomatoid Mesothelioma cases are caused due to asbestos exposure. Mainly to workers who were exposed to asbestos in the workplace, for instant Miners, insulators, ship builders and many more.
Asbestos fibers are very tiny small and light. Inhaling these fibers in big amounts for a long period of time cause people to develop mesothelioma. The mesothelioma cancer may develop decades after first exposure to asbestos and can metastases or spread quickly to other parts of the body.
Histologically, the mesothelioma cell types in Sarcomatoid mesothelioma are elongated and spindle-shaped; this is because this type of tumor has also been called sarcomatous, diffuse malignant fibrous and spindled mesothelioma.
Sarcomatoid cells have no nucleus and the cells are arranged in a rather haphazard way (do not bundle themselves) unlike epithelioid cells.This contributes to the cells’ ability to spread faster than other cell types.
The desoplastic variety of sarcomatoid mesothelioma is difficult to distinguish from healthy tissue because sometimes these cells have multiple nuclei or other cancers cells in many cases, because of the similarity to other benign and malignant conditions in appearance making an accurate mesothelioma diagnosis challenging. The sarcomatoid mesothelioma tumor cells resemble those of sarcoma tumors and localized fibrous tumors of the pleura.
Thus when accurate diagnosis are imperative the treatment depends mainly on the cancer’s stage and your overall health.
Sarcomatoid mesothelioma is unique in its diagnosis and treatment, it is challenging because the cells can resemble other cancers and the most resistant to cancer therapies…This is why Sarcomatoid Is the Most Aggressive Cell Type.
Symptoms of sarcomatoid mesothelioma are like all mesothelioma caner. Once mesothelioma symptoms have been detected with a history of asbestos exposure determined, the next step is to have an imaging test – initially with x-rays, followed up by CT scan or MRI.
However, to determine the cell type for a diagnosis after any reveal of serious abnormalities, a biopsy (tissue samples) will be planned to retrieve tumor tissue.
But a misdiagnosis is a chance because most sarcomatoid mesotheliomas cells are difficult to distinguish and do contain cells that resemble other cell of unrelated sarcomatoid cancers such as benign fibrous tissue. Thus it is a good idea to get a second and even a third opinion or have an immunohistochemistry using a large panel of markers if sarcomatoid mesothelioma is suspected to distinguish from other tumors.
Treatment Options:
Sarcomatoid mesothelioma histology and mixed tumors are unfavorable and the sarcomatoid cell types are difficult to treat and notoriously resistant to treatment because it is the most aggressive cell type of mesothelioma. As with other mesothelioma cell types treatment depends on the location and stage of the cancer, treatment is through some combination of surgery, radiation therapy, and chemotherapy, the same used for other cell types of this cancer but in fact the details differs depending on the individual case. The average mesothelioma survival rate is seven months, but with new advances, but we have a great hope on researchers increasing the survival rates over the next few years.
Surgery in particular can be difficult because these tumors are very rigid when it attaches to the chest wall it is difficult to remove and when the tumor is around the intestines which also make it harder to remove in both cases its removal is challenging.
Although Chemotherapy has also displayed limited success rates for this cell type to shrinkage, there have been new discoveries made. However, a promising drug called selenite has proven effective for types of mesothelioma, including this cell type when used in combination with doxorubicin. Selenite in combination with doxorubicin drug induced apoptosis (cell death).
Sarcomatoid histology and mixed tumors are unfavorable and its prognosis is not as positive as other mesothelioma cell types. A patient’s prognosis is largely dependent upon the cancer’s stage and the treatment available options. However, statistic survival rate have been inspected from 6 months up to six years past their initial diagnosis of sarcomatoid mesothelioma date depending on factors like age and overall health.


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