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Immunotherapy Treatment for Mesothelioma

What Is Immunotherapy Treatment for Mesothelioma?
Immunotherapy is a type of cancer treatment. Immunotherapy uses parts of the patient’s immune system to help them fight a disease, including different kinds of cancer.
Immunotherapy is also known as biological therapy, biotherapy, or biological response modifier (BRM) therapy. Biological therapy is a type of cancer treatment designed to use substances made from several materials. These materials either made by the body or in a laboratory, to treat cancer by improve, target, or restore immune system function.
How Does Immunotherapy Treatment Work?
Our immune system has evolved to protect the body. It helps your body fight infections and other diseases.  It also removes damaged or dead cells, but does not normally react to or destroy cancer cells. It is made up of white blood cells and organs and tissues of the lymph system, when they function normally they destroy only cells that are recognized as foreign cells. Foreign cells  are such as bacteria and viruses. Because cancer cells are produced by our bodies they are not recognized them as foreign ones.
Immunotherapy attempts to convince the immune system; to recognize that cancer cells are foreign thus helping the immune system to work better. Its function is to destroy cancer cells by stopping or slowing the growth of cancer cells and stopping cancer from spreading to other parts of the body.

Immunotherapy Treatment for Mesothelioma

The Immune System and Immunotherapy;
The body’s immune system can tell the difference between cells; cells that are part of the body and cells that are foreign.
A substance which causes the immune system to recognize the difference between cells produced by the body and foreign bodies then react and attack is called an antigen. The immune system identifies and reacts to antigens. Antigens are molecules that are present on the surface of any cell whether human, bacterial or viral.
A normal immune system will destroy cells that make foreign antigens produced by invaded bacteria, viruses and other foreign substances. These substances use the body for harm and are not normally found in it. But it won’t react to a cell that has an antigen that is produced by the body, even if it is a foreign cell like cancer.
The concept of Immunotherapy Treatment for Mesothelioma is to force the immune system into recognizing the antigens. And destroy  anything attached to it found on cancer cells are foreign.
Immunotherapy Treatment for Mesothelioma is not a cure for mesothelioma. When immunotherapy is administered to cancer patients, it eventually achieve improved results, making the immune system to destroy cancer cells while leaving normal healthy cells unharmed.
Immunotherapy Treatment for Mesothelioma;
The therapeutic objective of the immune mechanisms is to favor the recognition of tumor cells. The immune system target specific antigens to cancer cells and  generate immunological memory to ensure long-term remission.
Two approaches researchers take when they develop anti-tumor immunotherapy: passive immunotherapy and active immunotherapy. There is some evidence that mesothelioma cells are susceptible to an immunotherapy treatment. These two types of immunotherapies depend on how it is developed and administered to the patient and it may include:
Passive Immunotherapy;
Passive immunotherapy or adoptive immunotherapy; a treatment are made by using components not found in the patient’s body. Passive immunotherapy does not aim to activate the immune system in a systematic manner in situ. It relies on components created outside the body. It is isolated and activated in vitro before their re-injection. Some cancer cells are taken from the patient and put through a process. That produces antibodies that recognize the cancer antigens. These injected antibodies bind themselves to the tumor cells, so the immune system recognizes these antibodies and destroys the cancer cells.
Active Immunotherapy;
Active immunotherapy, or adaptive immunotherapy, also called “vaccination”.  Although it is therapeutic; it is to trigger the immune system (the body’s own defense line) to consist one or several antigens. Antigens to fight diseases that are already in the body in an ideal context of stimulation. The mesothelioma vaccine is created by either entire cancer cells are taken from the patient, or only the antigens are removed from the cells. A procedure is made in the laboratory. It make them be recognizable by the patient’s immune system, when they are re-injected into the patient.
Non-specific Immunotherapy;
Non-specific immunotherapies and adjuvants are both active and passive immunotherapy stimulate the body’s immune system. They create cells or antibodies. Non-specific immunotherapy does not use cells from the patient to show activity against cancer cells.
What is the Difference between active and passive immunotherapy;
Naturally acquired is a passive Immunotherapy; occurs when the person becomes immune as a result of the primary immune response in his own body.
Artificially acquired is an Active Immunotherapy by a vaccine that substance which contains the antigen.
Multimodal and Immunotherapy Strategies;
To date, there is no validated immunotherapy for efficient treatment of mesothelioma. All is only one promising new trends in the treatment for both immunotherapy and systemic chemo-immunotherapy. All on a hope that patient can be treated efficiently. However, one cannot exclude the possibility of future immunotherapy trials (cell therapy) associated with first line treatment using a relevant chemotherapy.


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